SMBA 1
2-[(2-Nitrofluoren-9-ylidene)methyl]phenol
CAS: 906440-37-7
Molecular Formula: C20H13NO3
SMBA 1 - Names and Identifiers
SMBA 1 - Physico-chemical Properties
| Molecular Formula | C20H13NO3 |
| Molar Mass | 315.32 |
| Density | 1.392±0.06 g/cm3(Predicted) |
| Boling Point | 502.0±38.0 °C(Predicted) |
| Solubility | DMSO |
| pKa | 9.22±0.30(Predicted) |
| Storage Condition | -20℃ |
| Use | SMBA1 is a selective acrivator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis. |
SMBA 1 - Reference
| Reference Show more | 1: Levesley J, Steele L, Brüning-Richardson A, Davison A, Zhou J, Ding C, Lawler S, Short SC. Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells. Neuro Oncol. 2018 Jan 22;20(2):203-214. doi: 10.1093/neuonc/nox134. PubMed PMID: 29016820. 2: Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus AI, Sun SY, Chen ZG, Sica GL, Ramalingam SS, Magis AT, Fu H, Khuri FR, Curran WJ, Owonikoko TK, Shin DM, Zhou J, Deng X. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017 Jun 1;77(11):3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5. PubMed PMID: 28381544; PubMed Central PMCID: PMC5503158. 3: Daniele S, Pietrobono D, Costa B, Giustiniano M, La Pietra V, Giacomelli C, La Regina G, Silvestri R, Taliani S, Trincavelli ML, Da Settimo F, Novellino E, Martini C, Marinelli L. Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells. ACS Chem Neurosci. 2018 Jan 17;9(1):85-99. doi: 10.1021/acschemneuro.7b00023. Epub 2017 Apr 11. PubMed PMID: 28368610. 4: Xin M, Li R, Xie M, Park D, Owonikoko TK, Sica GL, Corsino PE, Zhou J, Ding C, White MA, Magis AT, Ramalingam SS, Curran WJ, Khuri FR, Deng X. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014 Sep 17;5:4935. doi: 10.1038/ncomms5935. PubMed PMID: 25230299; PubMed Central PMCID: PMC4172359. |
SMBA 1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.171 ml | 15.857 ml | 31.714 ml |
| 5 mM | 0.634 ml | 3.171 ml | 6.343 ml |
| 10 mM | 0.317 ml | 1.586 ml | 3.171 ml |
| 5 mM | 0.063 ml | 0.317 ml | 0.634 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 2-[(2-Nitrofluoren-9-ylidene)methyl]phenol Visit Supplier Webpage Request for quotation
CAS: 906440-37-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 906440-37-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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